The first chapter of Grand Theft Auto IV begins in Broker, Liberty City, where you take missions from Roman Bellic, Little Jacob and a group of hardcore Eastern European characters. During this chapter, Niko reveals his motivations for coming to Liberty City.

You now have a new safehouse in Bohan, after the last one was burned down by the Russians. Roman says it's time to "start over again." In this chapter, Mallorie introduces you to two of her friends - Manny Escuela and Elizabeta Torres - both of whom provide work for Niko. Algonquin is unlocked after the mission "Blow Your Cover," and Alderney becomes unlocked at the end of the chapter.

In this chapter, Niko has an opportunity to work under mobsters Ray Boccino, Phil Bell and Jimmy Pegorino. The mafia agrees to help Niko look for the person that betrayed him in exchange for doing some work. This chapter also sees Niko get closer to the McReary family, both in working and social terms.

In this last section of the game, Niko is forced to make a decision which will have major impacts on the final outcome of the story. There are two possible outcomes, so it is recommended that you save your progress before making the decision, and that way you can go back later and try the alternative outcome.